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  • 歡迎訪問云南西力生物技術股份有限公司!證券代碼:871574
    首頁 成 果 源于西力產品的客戶論文
    Dual Effect of Glucuronidation of a Pyrogallol-Type Phytophenol Antioxidant: A Comparison between Scutellarein and Scutellarin. Molecules, 2018, 23: 3225.
    發布時間:2019-04-17 閱讀數:785 來源:Molecules
    分享到:

    Abstract:

    To explore whether and how glucuronidation affects pyrogallol-type phytophenols, scutellarein and scutellarin (scutellarein-7-O-glucuronide) were comparatively investigated using a set of antioxidant analyses, including spectrophotometric analysis, UV-vis spectra analysis, and ultra-performance liquid chromatography coupled with electrospray ionization-quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) analysis. In spectrophotometric analyses of the scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH●),2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+●), and 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radicals (PTIO●)and the reduction ofCu(2+) ions, scutellarein showed lower IC50values than scutellarin. However, in●O2ˉ-scavenging spectrophotometric analysis, scutellarein showed higher IC50value than scutellarin. The analysis of UV-Vis spectra obtained after the Fe(2+)-chelating reaction of scutellarin showed a typical UV-Vis peak (λmax= 611 nm), while scutellarein showed no typical peak. In UPLC-ESI-Q-TOF-MS/MS analysis, mixing of scutellarein with DPPH●yielded MS peaks (m/z 678, 632, 615, 450, 420, 381, 329, 300, 288, 227, 196, 182, 161, and 117) corresponding to the scutellarein-DPPH adduct and an MS peak (m/z 570) corresponding to the scutellarein-scutellarein dimer. Scutellarin, however, generated no MS peak. On the basis of these findings, it can be concluded that glucuronidation of pyrogallol-type phytophenol antioxidants has a dual effect. On the one hand, glucuronidation can decrease the antioxidant potentials (except for●O2ˉscavenging) and further lower the possibility of radical adduct formation (RAF), while on the other hand, it can enhance the●O2ˉ-scavenging and Fe(2+)-chelating potentials.



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